2000g-441 2006h-552 2014b-667 animal animaldiseasemodels animalmodels animalmodelsinresearch breeding cardiovascularphysiologicalphenomena chimera congresses design diseasemodels diseases drugdesign drugdevelopment drugdiscovery drugs effectofdrugson embryology embryos geneticengineering genetics heart immunology laboratorymanuals majorhistocompatibilitycomplex mice miceaslaboratoryanimals molecularaspects mutagenesis pharmaceuticalindustry pharmaceuticaltechnology phenotype physiologicaleffect physiology preclinicaldrugevaluation qy25 transgenic wg102c2671522001 wo680t77041990