2000g-441 2003b-118 2006j-444 adverseeffects breeding cellularcontrolmechanisms cloning congresses crispr-cassystems cropimprovement dd6197 dnadamage dnarepair foodadditives foodpreservatives genetic geneticallymodified geneticrecombination geneticregulation genetics genetictechniques genome insertional invitrotechniques laboratorymanuals meiosis methodology methods mice miceaslaboratoryanimals molecular molecularcloning nitrates nitrites nitrogenoxides nitrosocompounds organisms pharmacology plantbiotechnology plantgenetics plantmutationbreeding polymerasechainreaction qh441h396a2003 qu477d62952006 recombinantdna recombinases recombination research site-directed toxicology transgenic transgenicmice