2007f-282 cellcycle combinatorialchemistry combinatorialchemistrytechniques crispr-cassystems dna dnarepair geneexpression genelibraries genelibrary generearrangement genes genetic geneticallymodified geneticengineering genetics immunesystem immunoglobulinclassswitching immunology laboratorymanuals metabolism methods microbialmutation molecularevolution moleculargenetics mutagenesis organisms physiology qh443r31092004 qh443w593g1982 qu475m7182007 qw541m7171996 rag-1 recombinantdna recombinases recombination site-directed