analysis antisense antisensedna browsers(computerprograms) chemicalsynthesis combinatorialchemistry combinatorialchemistrytechniques complementary databases dataprocessing directedmolecularevolution dna drugdiscovery enzymes genelibraries genetic geneticengineering geneticrecombination genetictechniques genomics laboratorymanuals methods microbialmutation molecularbiology molecularevolution proteinengineering qu135d5982003 qu25g3262003 qu470s312g2008 qv744 rs420 smallmoleculelibraries software synthesis technique user-computerinterface