2011l-129 2015e-369 biological biopharmaceutics chemicalreactions chemicalsynthesis cheminformatics chemistry combinatorialchemistry combinatorialchemistrytechniques dataprocessing design dna drugdesign drugdevelopment drugdiscovery drugs genelibrary metabolism methods models organiccompounds pharmaceutical pharmaceuticalchemistry pharmaceuticalpreparations pharmacokinetics pharmacologicalphenomena proteins rs418 rs419 rs420 smallmoleculelibraries synthesis systemsbiology technique textbooks