adverseeffects clinicalmedicine diseases drugdeliverysystems drugtherapy environmentalexposure evidence-basedmedicine fitness general health internalmedicine lung lungdiseases medical metabolism nanoparticles nanoparticules nanostructuredmaterials pharmacologiepulmonaire pulmonarypharmacology pulmonarytoxicology riskassessment toxicologiepulmonaire évaluationdurisque