blood-brainbarrier centralnervoussystem centralnervoussystemagents centralnervoussystemdiseases control drug-relatedsideeffectsandadversereactions drugdevelopment drugdiscovery drugeffects drugtherapy medical mentaldisorders metabolism methods molecularneurobiology neuropharmacology pharmacokinetics pharmacology physiology prevention psychopharmacology psychotropicdrugs qv77 wl200