animalmodels autonomicnervoussystem blood-brainbarrier brain braindiseases centralnervoussystem centralnervoussystemdiseases clinicaltrials control drug-relatedsideeffectsandadversereactions drugdeliverysystems drugdesign drugdevelopment drugdiscovery drugeffects drugevaluation drugs drugscreening drugtargeting drugtherapy economics effectofdrugson financialsupport medical mentalillness metabolism methodology methods molecularneurobiology nervoussystemdiseases neuropharmacology neuropsychopharmacology pharmacokinetics pharmacology physiology prevention privatesector psychopharmacology research researchdesign rm315 testing wl200