20thcentury biography brain buprenorphine diseases drugabuse drugaddicts drugcontrol drugmonitoring drugmonitoring[mesh] drugoverdose drugtherapy drugusers etc europeanunioncountries governmentpolicy heroin heroinabuse history kk3289 lawandlegislation laws legalstatus methadone methadone[mesh] naloxone naltrexone newyork newyork(state) opiatesubstitutiontreatment opioid-relateddisorders opioidabuse opioids overdose patients prevention rehabilitation substance-relateddisorders therapeuticuse therapy treatment unitedstates wm270 wm270c866a1989 wm288n419m1973