adversedrugreactionreportingsystems adverseeffects analysis antimalarials chromatography co corruptpractices drugabuse drugmonitoring[mesh] drugs drugutilizationreview europeanunioncountries governmentpolicy lawandlegislation liquid liquidchromatography massspectrometry medical merck methadone[mesh] methadonemaintenance methods pharmaceuticalpreparations pharmacoepidemiology pharmacology postmarketing postmarketingproductsurveillance productsurveillance rofecoxib safetymanagement safetymeasures sideeffects standards substanceabusedetection terminologyastopic testing treatment vaccines