2011b-667 2012f-386 2013f-789 biotechnology business clinicaltrials clinicaltrialsastopic computersimulation corruptpractices drugadulteration drugapproval drugdevelopment drugdiscovery drugevaluation drugindustry drugs economics generic genericdrugs industries jurisprudence lawandlegislation legislation medical mesuresdesécurité methods models médicaments pharmaceutical pharmaceuticalindustry pharmaceuticalpreparations pharmaceuticaltechnology pharmacoepidemiology pharmacology pharmacovigilance postmarketing preclinical productsurveillance publicpolicy qualitycontrol qv771t34452013 rm300 safetymeasures standards statisticalmethods statisticsastopic technology testing theoretical toxicitytests toxicologie toxicology unitedstates