2013h-856 2017a-147 administration adverseeffects control deliveryofhealthcare design drug-relatedsideeffectsandadversereactions drugdevelopment druginteractions drugs economics effectofchemicalson environmentalexposure healthpolicy mammals medical medicine metabolism methods organization pharmacology pharmacovigilance poisoncontrolcenters poisoning poisons prevention proteinkinaseinhibitors publichealthpractice riskassessment rs420 sideeffects textbooks toxicity toxicitytesting toxicitytests toxicologicalphenomena toxicology