abnormalities adnmitochondrial aging animal biochemistry bioenergetics celldeath cellmetabolism cellularsenescence congresses diseasemodels diseases dna energymetabolism formation freeradicals freeradicals(chemistry) genetics laboratorymanuals lifesciences lipidmetabolism maladiesmitochondriales medical metabolism mitochondria mitochondrial mitochondrialdiseases mitochondrialdna mitochondries molecularaspects nervoussystem nervoussystemdiseases neurons oxidativestress pathology pathophysiology physiology physiopathology science stressoxydatif therapy treatment ultrastructure