1999d-220 adenoviridae adenoviruses biotechnology cells celltransformation cloning dependovirus eukaryoticcells geneexpression geneexpressionregulation genetherapy geneticengineering genetics genetictherapy genetictransformation genetransfertechniques humangenetics humansgeneticdisorderstherapy immunesystem immunology laboratorymanuals methodology methods molecular molecularcloning neoplastic oncogenicviruses parvoviruses pichia pichiapastoris prokaryoticcells qr396 qw25 qw25c913p2007 qz25g3262008 qz50a2321996 qz50d48851999 recombinantproteins virology yeastfungi