accidents adverseeffects butadiene butadienes carcinogenicity carcinogens chemicalcarcinogenesis chemicallyinduced control equipmentandsupplies etc handbooks hospital manuals medicalinstrumentsandapparatus methods neoplasms occupational prevention qz202i103z2008 riskassessment safetymeasures standards sterilization toxicology vinylbromide vinylchloride vinylcompounds vinylhalides wx185d186e1986