adverseeffects butadiene butadienes carcinogenesis carcinogenicity carcinogens chemicallyinduced congresses dose-responserelationship drug environmentalpollution environmentaltoxicology ethyleneoxide healthriskassessment industrialtoxicology industrialwaste neoplasms probability qz202i103z2008 qz202p9441997 qz202q1051979 qz202u17m1981 ra1226 risk riskassessment toxicology vinylbromide vinylchloride vinylcompounds vinylhalides