2005e-338 applied biometrics biometry biométrie biostatistics clinicaltrials clinicaltrialsastopic evaluation general healthcare healthstatusindicators indicateursdesanté kwaliteitvanhetbestaan longitudinalstudies mathematics measurement medical medicine méthodesstatistiques numericaldata outcomeassessment pharmacology probability qualityoflife qualitédelavie research statisticalmethods statistics étudeslongitudinales évaluation