administration animal biocompatiblematerials bonetransplantation clinicaltrialsastopic diffusionofinnovation drugdeliverysystems drugdiscovery drugevaluation drugtherapy evidence-basednursing healthcaredisparities methods minorityhealth models nervoussystemdiseases organization preclinical researchdesign socialdeterminantsofhealth socioeconomicfactors tissueengineering wl140