2012a-122 2012c-941 biochemistry biological biopharmaceutics cellreceptors clinical clinicalpharmacology design drugdesign drugdiscovery drugeffects drugs drugtherapy g-protein-coupled genetics gproteins hazardoussubstances lifesciences mathematicalmodels methods models oligonucleotidearraysequenceanalysis pathological pharmacokinetics pharmacologicalphenomena pharmacology physiology receptors riskassessment science statistical structure-activityrelationship structure-activityrelationships toxicity toxicogenetics