610 aminoacids biochemistry biology biomedicine biomedicinegeneral biophysicsandbiologicalphysics cellculture cellculturetechniques chemistry chemistry/foodscience general isotopelabeling laboratorymanuals lifesciences massspectrometry medicine methods microbiology physicalandtheoretical physicalorganicchemistry protein-ligandinteractions proteomics r-rz rna-ligandinteractions silac stableisotopelabelingbyaminoacidsincellculture stableisotopes