acidearachidonique arachidonicacid arachidonicacids cellularimmunity immuneresponse immunite immunity immunologicdiseases immunologie immunology leucotrieneb4 leucotrienes leukotriene leukotrieneb4 leukotrienes maladiesimmunologiques metabolism pathophysiology physiopathologie prostaglandines prostaglandins reactionimmunitaire regulation reponseimmunitaire srs-a