adaptation brain cancercells cellsurface celltransformation congresses development endocrinesystem epidermalgrowthfactor fibroblastgrowthfactor glucuronidase growth growthfactors growthsubstances metabolism neoplasms neoplastic nervegrowthfactor nervegrowthfactors nerves neuralcircuitry neuronalplasticity neuroplasticity neurotrophicfunctions oncogenes physiology physiopathology qu107 qz202o77g1987 receptors regulation wl300n49381731987